2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid

Base Information

• Chemical Name: 2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid
• CAS No.: 111751-14-5
• Molecular Formula: C₁₉H₁₉ClO₅
• Molecular Weight: 362.81

Synonyms:2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid

Chemical Property of 2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid

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Technology Process of 2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid

There total 1 articles about 2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-(p-chlorophenyl)-2-oxobutanoic acid (76400-21-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid (111751-14-5)

Guidance literature:

With potassium hydroxide; In water; at 0 ℃; for 48h;

DOI:10.1002/jhet.5570240114

Reference yield: 95.0%

2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid (111751-14-5) → (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid (111751-17-8)

Guidance literature:

With hydrogenchloride; In acetic acid; for 3h; reflux on a water-bath;

DOI:10.1002/jhet.5570240114

Reference yield: 53.0%

2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid (111751-14-5) → 4-[2-(4-Chloro-phenyl)-ethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one (111751-21-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1002/jhet.5570240114

upstream raw materials:

4-(p-chlorophenyl)-2-oxobutanoic acid

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

(E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid

4-[2-(4-Chloro-phenyl)-ethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one

2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one

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