(2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane

Base Information

• Chemical Name: (2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane
• CAS No.: 1354960-72-7
• Molecular Formula: C₁₂H₁₆ClF₃OSi
• Molecular Weight: 296.792
• Mol file: 1354960-72-7.mol

Synonyms:(2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane

Chemical Property of (2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane

Chemical Property:

Purity/Quality:

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Technology Process of (2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane

There total 1 articles about (2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + 2-chloro-4-fluoro-1-(trifluoromethyl)benzene (94444-58-3) → (2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane (1354960-72-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 31.0%

(2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane (1354960-72-7) → 2-chloro-4-hydroxybenzotrifluoride (37900-81-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

(2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane (1354960-72-7) → 5-chloro-4-(3-chloro-4-(trifluoromethyl)phenoxy)-2-fluoro-N-(methylsulfonyl)benzamide (1354955-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / 1,4-dioxane; tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

upstream raw materials:

2-(Trimethylsilyl)ethanol

2-chloro-4-fluoro-1-(trifluoromethyl)benzene

Downstream raw materials:

2-chloro-4-hydroxybenzotrifluoride

5-chloro-4-(3-chloro-4-(trifluoromethyl)phenoxy)-2-fluoro-N-(methylsulfonyl)benzamide