2-CHLORO-4-FLUOROBENZOTRIFLUORIDE

Base Information

• Chemical Name: 2-CHLORO-4-FLUOROBENZOTRIFLUORIDE
• CAS No.: 94444-58-3
• Molecular Formula: C7H3ClF4
• Molecular Weight: 198.547
• Hs Code.: 2903999090
• Mol file: 94444-58-3.mol

Synonyms:2-Chloro-4-fluoro-1-(trifluoromethyl)benzene;

Chemical Property of 2-CHLORO-4-FLUOROBENZOTRIFLUORIDE

Chemical Property:

• Vapor Pressure: 5.25mmHg at 25°C
• Melting Point: -42 °C
• Refractive Index: 1.432
• Boiling Point: 148.9 °C at 760 mmHg
• Flash Point: 48.9 °C
• PSA: 0.00000
• Density: 1.427 g/cm³
• LogP: 3.49790
• Storage Temp.: Room temperature.

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-4-fluoro-1-trifluoromethylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-4-fluoro-1-trifluoromethylbenzene

Technology Process of 2-CHLORO-4-FLUOROBENZOTRIFLUORIDE

There total 2 articles about 2-CHLORO-4-FLUOROBENZOTRIFLUORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

→ 2-chloro-4-fluoro-1-(trifluoromethyl)benzene (94444-58-3)

Guidance literature:

With trichloroisocyanuric acid; bromine; In tetrachloromethane; at -10 - 100 ℃; for 18h; Photolysis;

Reference yield:

3-Chloro-4-trifluoromethyl-nitrobenzene (151504-80-2) → 2-chloro-4-fluoro-1-(trifluoromethyl)benzene (94444-58-3)

Guidance literature:

With potassium fluoride; tetraphenylphosphonium bromide; In dimethyl sulfoxide; at 130 ℃; for 5h;

DOI:10.1016/S0022-1139(00)80394-2

Reference yield: 94.0%

2-chloro-4-fluoro-1-(trifluoromethyl)benzene (94444-58-3) → 1-chloro-5-fluoro-4-nitro-2-(trifluoromethyl)benzene (862874-18-8)

Guidance literature:

With sulfuric acid; potassium nitrate; at -10 - 30 ℃; Inert atmosphere;

upstream raw materials:

3-Chloro-4-trifluoromethyl-nitrobenzene

Downstream raw materials:

1-chloro-5-fluoro-4-nitro-2-(trifluoromethyl)benzene

(2-(3-chloro-4-(trifluoromethyl)phenoxy)ethyl)trimethylsilane

2-chloro-4-hydroxybenzotrifluoride

5-chloro-4-(3-chloro-4-(trifluoromethyl)phenoxy)-2-fluoro-N-(methylsulfonyl)benzamide

Refernces

• 1、 Beaumont, Andrew J.,Clark, James H.,Boechat, Nubia A.. "Selective fluorodenitration of chloronitroaromatics". . p. 25 - 30. Retrieved 2007/10/02.