3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

Base Information

Chemical Name:3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane
CAS No.:651031-27-5
Molecular Formula:C₃₁H₄₉NO₆Si
Molecular Weight:559.819
Hs Code.:

Synonyms:3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

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Chemical Property of 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

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Technology Process of 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

There total 8 articles about 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 79069-15-1
N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol

: 651031-26-4
(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

: 651031-27-5
3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

Guidance literature:: N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol; With sodium hydride; In tetrahydrofuran; for 0.25h; cooling;

(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate; In tetrahydrofuran; for 2.16667h;
DOI:10.1021/ol035998s

Reference yield:

: 17325-85-8
(2S)-3-(benzyloxy)propane-1,2-diol

: 651031-27-5
3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / -78 °C

2.1: 77 percent / CH₂Cl₂ / -78 - 20 °C

3.1: NaH / tetrahydrofuran / 0.25 h / cooling

3.2: 81 percent / tetrahydrofuran / 2.17 h

With 2,6-dimethylpyridine; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol035998s

Reference yield:

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

: 651031-27-5
3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(tert-butyldimethylsilyloxy)propane

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / CH₂Cl₂

2.1: LiBH₄ / diethyl ether

3.1: NaH; TBAI / tetrahydrofuran

4.1: pyridinium p-toluenesulfonate / ethanol / 60 °C

5.1: NaH / tetrahydrofuran / 0.25 h / cooling

5.2: 81 percent / tetrahydrofuran / 2.17 h

With lithium borohydride; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ol035998s