(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

Base Information

Chemical Name:(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate
CAS No.:651031-26-4
Molecular Formula:C₁₇H₂₇F₃O₅SSi
Molecular Weight:428.545
Hs Code.:

Synonyms:(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of (2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

There total 3 articles about (2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: (2R)-3-benzyloxy-2-hydroxypropyl trifluoromethanesulfonate

: 651031-26-4
(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

Guidance literature:: In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol035998s

Reference yield:

: 17325-85-8
(2S)-3-(benzyloxy)propane-1,2-diol

: 651031-26-4
(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / -78 °C

2: 77 percent / CH₂Cl₂ / -78 - 20 °C

With 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1021/ol035998s

Reference yield:

: 100-39-0
benzyl bromide

: 651031-26-4
(2R)-3-benzyloxy-2-tert-butyldimethylsilyloxypropyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH; TBAI / tetrahydrofuran

1.2: 94 percent / aq. AcOH

2.1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / -78 °C

3.1: 77 percent / CH₂Cl₂ / -78 - 20 °C

With 2,6-dimethylpyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol035998s