(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

Base Information

Chemical Name:(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal
CAS No.:238421-72-2
Molecular Formula:C₂₂H₃₆O₅Si
Molecular Weight:408.61
Hs Code.:

Synonyms:(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

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Technology Process of (2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

There total 5 articles about (2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 238421-71-1
(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

: 238421-72-2
(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

Guidance literature:: With lead(IV) acetate; In benzene; at 20 ℃; for 0.0833333h;

Reference yield:

: 238421-40-4
(5S)-4-hydroxy-3-(4-methoxyphenyl)-5-(2-propyl)-2(5H)-furanone

: 238421-72-2
(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / Et₃N / tetrahydrofuran / 24 h / 30 °C

2: p-TsOH*H₂O / benzene / 0.5 h / Heating; Dean-Stark apparatus

3: 98 percent / LiAlH₄ / tetrahydrofuran / 4.5 h / Heating

4: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 15 h / 20 °C

5: 89 percent / Pb(OAc)4 / benzene / 0.08 h / 20 °C

With lead(IV) acetate; dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: Addition / 2: ketalization / 3: Reduction / 4: silylation / 5: Oxidation;

Reference yield:

: 238421-61-9
(3R,5S)-3-(4-methoxyphenyl)-3-(3-oxobutyl)-5-(2-propyl)-2,4(3H,5H)-furadione

: 238421-72-2
(2S)-2-(tert-butyldimethylsilyloxymethyl)-5,5-ethylenedioxy-2-(4-methoxyphenyl)hexanal

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH*H₂O / benzene / 0.5 h / Heating; Dean-Stark apparatus

2: 98 percent / LiAlH₄ / tetrahydrofuran / 4.5 h / Heating

3: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 15 h / 20 °C

4: 89 percent / Pb(OAc)4 / benzene / 0.08 h / 20 °C

With lead(IV) acetate; dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: ketalization / 2: Reduction / 3: silylation / 4: Oxidation;