(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

Base Information

Chemical Name:(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol
CAS No.:238421-71-1
Molecular Formula:C₂₆H₄₆O₆Si
Molecular Weight:482.733
Hs Code.:

Synonyms:(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

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Chemical Property of (1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

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Technology Process of (1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

There total 4 articles about (1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: (1S,3S)-6,6-ethylenedioxy-2-hydroxy-3-hydroxymethyl-3-(4-methoxyphenyl)-1-(2-propyl)-heptanol

: 238421-71-1
(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 238421-40-4
(5S)-4-hydroxy-3-(4-methoxyphenyl)-5-(2-propyl)-2(5H)-furanone

: 238421-71-1
(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Et₃N / tetrahydrofuran / 24 h / 30 °C

2: p-TsOH*H₂O / benzene / 0.5 h / Heating; Dean-Stark apparatus

3: 98 percent / LiAlH₄ / tetrahydrofuran / 4.5 h / Heating

4: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 15 h / 20 °C

With dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: Addition / 2: ketalization / 3: Reduction / 4: silylation;

Reference yield:

: 238421-61-9
(3R,5S)-3-(4-methoxyphenyl)-3-(3-oxobutyl)-5-(2-propyl)-2,4(3H,5H)-furadione

: 238421-71-1
(1S,3S)-3-(tert-butyldimethylsilyloxymethyl)-6,6-ethylenedioxy-2-hydroxy-3-(4-methoxyphenyl)-1-(2-propyl)heptanol

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH*H₂O / benzene / 0.5 h / Heating; Dean-Stark apparatus

2: 98 percent / LiAlH₄ / tetrahydrofuran / 4.5 h / Heating

3: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 15 h / 20 °C

With dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: ketalization / 2: Reduction / 3: silylation;