Amesergide

Base Information

Chemical Name:Amesergide
CAS No.:121588-75-8
Molecular Formula:C25H35 N3 O
Molecular Weight:393.572
Hs Code.:
UNII:EJL329H95R
DSSTox Substance ID:DTXSID8052851
Nikkaji Number:J273.411G
Wikipedia:Amesergide
Wikidata:Q27074433
NCI Thesaurus Code:C169779
Pharos Ligand ID:L1XJV3GNV1SX
ChEMBL ID:CHEMBL160293
Mol file:121588-75-8.mol

Synonyms:amesergide;LY 237733;LY-237733;LY237733

Suppliers and Price of Amesergide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
AMESERGIDE 95.00%
5MG
$ 498.59

Total 3 raw suppliers

Chemical Property of Amesergide

Chemical Property:

Vapor Pressure:6.77E-15mmHg at 25°C
Boiling Point:611.6°Cat760mmHg
Flash Point:323.7°C
PSA：40.76000
Density:1.25g/cm³
LogP:5.40930
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:393.278012748
Heavy Atom Count:29
Complexity:601

Purity/Quality:

98%,99%, ^*data from raw suppliers

AMESERGIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N1C=C2CC3C(CC(CN3C)C(=O)NC4CCCCC4)C5=C2C1=CC=C5
Isomeric SMILES:CC(C)N1C=C2C[C@@H]3[C@H](C[C@H](CN3C)C(=O)NC4CCCCC4)C5=C2C1=CC=C5
Uses Serotonin antagonist.
Therapeutic Function Serotonin antagonist

Technology Process of Amesergide

There total 2 articles about Amesergide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1336-21-6
ammonium hydroxide

: (8β)-1-isopropyl-6-methyl ergoline-8-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 543-27-1
isobutyl chloroformate

: 121588-75-8
amesergide

Guidance literature:: With potassium carbonate; In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; N,N-dimethyl-formamide;

Reference yield:

: 41710-27-4
(8β)-6-methyl-1-(1-methylethyl)ergoline-8-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 121588-75-8
amesergide

Guidance literature:: With potassium carbonate; isobutyl chloroformate; Multistep reaction; 1.) DMF, 140 deg C, 2.) from -45 deg C to room temp.;
DOI:10.1021/jm00164a029

Reference yield:

: 121588-75-8
amesergide

: 123700-98-1
(6aR,9R,10aR)-9-(1-Cyclohexyl-1H-tetrazol-5-yl)-4-isopropyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline

Guidance literature:: With pyridine; hydrogen azide; phosphorus pentachloride; Multistep reaction; 1.) ClCH₂CH₂Cl, 4 h, 2.) 16 h;
DOI:10.1021/jm00164a029