N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide

Base Information

• Chemical Name: N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide
• CAS No.: 1352874-65-7
• Molecular Formula: C₂₁H₁₆ClFN₄O
• Molecular Weight: 394.836

Synonyms:N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide

Chemical Property of N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide

Chemical Property:

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Technology Process of N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide

There total 1 articles about N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-bromo-phenyl)-6-fluoro-1H-benzoimidazol-2-ylamine (1283495-02-2) + 2-acetamido-5-chlorophenylboronic acid, pinacol ester (957063-08-0) → N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide (1352874-65-7)

Guidance literature:

With sodium carbonate; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.283333h; Micrwave irradiation;

Reference yield: 26.0%

N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide (1352874-65-7) + 4-(bromomethyl)benzimidazole-1-carboxylic acid,1,1-dimethylethyl ester (132873-77-9) → N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide (1352874-02-2)

Guidance literature:

With potassium iodide; In acetonitrile; at 110 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide (1352874-65-7) + tert-butyl 4-(bromomethyl)-1H-1-indolecarboxylate (220499-13-8) → 4-[3-(2'-acetylamino-5'-chloro-biphenyl-4-yl)-5-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-ylmethyl]-indole-1-carboxylic acid tert-butyl ester (1352874-64-6)

Guidance literature:

With potassium iodide; In acetonitrile; at 110 ℃; for 0.166667h; Microwave irradiation;

upstream raw materials:

1-(4-bromo-phenyl)-6-fluoro-1H-benzoimidazol-2-ylamine

2-acetamido-5-chlorophenylboronic acid, pinacol ester

Downstream raw materials:

N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

4-[3-(2'-acetylamino-5'-chloro-biphenyl-4-yl)-5-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

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