N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Base Information

Chemical Name:N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide
CAS No.:1352874-01-1
Molecular Formula:C₃₀H₂₃ClFN₅O
Molecular Weight:523.997
Hs Code.:

Synonyms:N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

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Chemical Property of N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

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Technology Process of N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

There total 6 articles about N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1352874-64-6
4-[3-(2'-acetylamino-5'-chloro-biphenyl-4-yl)-5-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

: 1352874-01-1
N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 220499-12-7
tert-butyl 4-(hydroxymethyl)-1H-1-indolecarboxylate

: 1352874-01-1
N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: carbon tetrabromide / dichloromethane / 0 °C

1.2: 1.17 h / 0 °C

2.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With carbon tetrabromide; trifluoroacetic acid; potassium iodide; In dichloromethane; acetonitrile;

Reference yield:

: 1313237-54-5
1-(tert-butyl) 4-methyl indoline-1,4-dicarboxylate

: 1352874-01-1
N-{5-chloro-4'-[6-fluoro-2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; cyclohexane / 16.33 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: carbon tetrabromide / dichloromethane / 0 °C

2.2: 1.17 h / 0 °C

3.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With carbon tetrabromide; diisobutylaluminium hydride; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; dichloromethane; cyclohexane; acetonitrile;