N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

Base Information

Chemical Name:N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide
CAS No.:1352874-02-2
Molecular Formula:C₂₉H₂₂ClFN₆O
Molecular Weight:524.985
Hs Code.:

Synonyms:N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

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Chemical Property of N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

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Technology Process of N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

There total 6 articles about N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1352874-65-7
N-[4'-(2-amino-6-fluoro-benzoimidazol-1-yl)-5-chloro-biphenyl-2-yl]-acetamide

: 132873-77-9
4-(bromomethyl)benzimidazole-1-carboxylic acid,1,1-dimethylethyl ester

: 1352874-02-2
N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

Guidance literature:: With potassium iodide; In acetonitrile; at 110 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 65658-13-1
(1H-benzo[d]imidazol-4-yl)methanol

: 1352874-02-2
N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydrogencarbonate / acetonitrile / 4 h / 20 °C

2: phosphorus tribromide; sodium hydrogencarbonate / diethyl ether; dichloromethane / 2.08 h / 0 - 20 °C / Argon atmosphere

3: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

With water; phosphorus tribromide; sodium hydrogencarbonate; potassium iodide; In diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 37619-25-3
methyl 1H-benzo[d]imidazole-4-carboxylate

: 1352874-02-2
N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h / 20 °C / Argon atmosphere

1.2: 1 h / 20 °C

2.1: water; sodium hydrogencarbonate / acetonitrile / 4 h / 20 °C

3.1: phosphorus tribromide; sodium hydrogencarbonate / diethyl ether; dichloromethane / 2.08 h / 0 - 20 °C / Argon atmosphere

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

With lithium aluminium tetrahydride; water; phosphorus tribromide; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;