3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol

Base Information

• Chemical Name: 3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol
• CAS No.: 350693-47-9
• Molecular Formula: C₁₈H₂₈OSi₂
• Molecular Weight: 316.591

Synonyms:3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol

Chemical Property of 3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol

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Technology Process of 3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol

There total 2 articles about 3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

chloro-trimethyl-silane (75-77-4) + (E)-benzalacetone (1896-62-4) + trimethylsilylacetylene (1066-54-2) → 3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol (350693-47-9)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃;

(E)-benzalacetone; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Further stages.;

DOI:10.1021/jo010157p

Reference yield:

(E)-benzalacetone (1896-62-4) + trimethylsilylacetylene (1066-54-2) → 3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol (350693-47-9)

Guidance literature:

trimethylsilylacetylene;

(E)-benzalacetone;

(CH₃)3SiX; Further stages.;

DOI:10.1021/ol0271537

Reference yield: 92.0%

3-(O-trimethylsilyl)-1-phenyl-3-methyl-5-trimethylsilyl-1-penten-4-yn-3-ol (350693-47-9) + 3,4-bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pent-2-ene → (2S)-tert-butyldimethylsilyloxy-4,4,7-trimethyl-9-trimethylsilyl-6-nonen-8-yn-3-one

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -30 ℃;

DOI:10.1021/ol0271537

upstream raw materials:

chloro-trimethyl-silane

(E)-benzalacetone

trimethylsilylacetylene

Downstream raw materials:

3-methyl-5-phenyl-1-trimethylsilyl-3(Z),7-octadien-1-yne

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