1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Base Information

Chemical Name:1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester
CAS No.:418754-95-7
Molecular Formula:C₂₂H₂₃F₃N₂O₄S
Molecular Weight:468.497
Hs Code.:

1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Synonyms:1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

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Chemical Property of 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

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Technology Process of 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

There total 1 articles about 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372162-73-7
5-bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 64-17-5
ethanol

: 124-38-9,18923-20-1
carbon dioxide

: 418754-95-7
1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: 5-bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; With isobutylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; for 2h;

ethanol; With hydrogenchloride; for 36h; Heating / reflux;

Reference yield:

: 418754-95-7
1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 418754-99-1
5-(Diazoacetyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 - 60 ℃; for 20h;

diazomethyl-trimethyl-silane; With triethylamine; In tetrahydrofuran; dichloromethane; for 72h;

Reference yield:

: 418754-95-7
1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 418755-01-8
5-(Chloroacetyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h;

diazomethyl-trimethyl-silane; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; for 18h;