(RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide

Base Information

• Chemical Name: (RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide
• CAS No.: 374819-29-1
• Molecular Formula: C₂₃H₂₁F₆NO₂
• Molecular Weight: 457.416
• Mol file: 374819-29-1.mol

Synonyms:(RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide

Chemical Property of (RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide

There total 1 articles about (RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-oxo-1-phenylcyclohexanecarboxylic acid (75945-91-4) + (RS)-α-methyl-3,5-bis(trifluoromethyl)benzenemethanamine (187085-97-8) → (RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide (374819-29-1)

Guidance literature:

4-oxo-1-phenylcyclohexanecarboxylic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

(RS)-α-methyl-3,5-bis(trifluoromethyl)benzenemethanamine; In dichloromethane; at 20 ℃; for 26h;

Reference yield: 72.0%

(RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide (374819-29-1) → cis-(RS)-4-hydroxy-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide

Guidance literature:

(RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide; With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.666667h;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.166667h;

Reference yield:

4-(4-fluorophenyl)piperidine (37656-48-7) + (RS)-4-oxo-1-phenyl-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}cyclohexanecarboxamide (374819-29-1) → 4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-amide + 4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-amide

Guidance literature:

With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃;

DOI:10.1016/S0960-894X(02)00249-4

upstream raw materials:

4-oxo-1-phenylcyclohexanecarboxylic acid

(RS)-α-methyl-3,5-bis(trifluoromethyl)benzenemethanamine