(2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid

Base Information

Chemical Name:(2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid
CAS No.:910040-98-1
Molecular Formula:C₂₇H₂₈N₂O₄S
Molecular Weight:476.596
Hs Code.:

Synonyms:(2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid

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Chemical Property of (2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid

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Technology Process of (2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid

There total 2 articles about (2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 68452-41-5
N,N-dibenzylpropargylamine

: 88452-86-2
(2S)-N-para-toluenesulfonylaziridine-2-carboxylic acid

: 910040-98-1
(2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid

Guidance literature:: N,N-dibenzylpropargylamine; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

(2S)-N-para-toluenesulfonylaziridine-2-carboxylic acid; In tetrahydrofuran; hexane; at 0 ℃; for 3.5h; Further stages.;
DOI:10.1039/b605026n

Reference yield:

: 100-39-0
benzyl bromide

: 910040-98-1
(2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 71 percent / aq. Na₂CO₃ / CH₂Cl₂ / 4 h / Heating

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / 0 °C

2.2: 61 percent / hexane; tetrahydrofuran / 3.5 h / 0 °C

With n-butyllithium; sodium carbonate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b605026n