N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Base Information

• Chemical Name: N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine
• CAS No.: 1306597-67-0
• Molecular Formula: C₄₁H₅₅N₅O₁₁Si₂
• Molecular Weight: 850.086

Synonyms:N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property of N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property:

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Safty Information:

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Technology Process of N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

There total 1 articles about N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (1306597-64-7) → N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (1306597-67-0)

Guidance literature:

With boron trichloride; In dichloromethane; at -78 ℃; for 4.5h;

DOI:10.1021/ol200971z

Reference yield: 55.0%

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (1306597-67-0) + 4,4'-dimethoxytrityl chloride (40615-36-9) → N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (1306597-68-1)

Guidance literature:

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine; 4,4'-dimethoxytrityl chloride; In pyridine;

In pyridine; acetic anhydride;

DOI:10.1080/15257770.2014.984073

Reference yield:

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine (1306597-67-0) + 4,4'-dimethoxytrityl chloride (40615-36-9) → C62H73N5O13Si2

Guidance literature:

With dmap; In pyridine; at 40 ℃; for 4h;

DOI:10.1021/ol200971z

upstream raw materials:

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Downstream raw materials:

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

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