N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Base Information

Chemical Name:N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine
CAS No.:1306597-69-2
Molecular Formula:C₆₇H₆₉N₅O₁₅Si
Molecular Weight:1212.39
Hs Code.:

N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

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Technology Process of N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

There total 9 articles about N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1306597-67-0
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

: 1306597-69-2
N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / pyridine / 4 h / 40 °C

2: pyridine / 16 h / 40 °C

3: methylamine / methanol; ethanol; dichloromethane / 0.5 h / 0 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

5: dmap / pyridine / 48 h / 50 °C

6: 16 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; methylamine; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane;
DOI:10.1021/ol200971z

Reference yield:

: 1306597-68-1
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

: 1306597-69-2
N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 4 steps

1: methylamine / methanol; ethanol; dichloromethane / 0.5 h / 0 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

3: dmap / pyridine / 48 h / 50 °C

4: 16 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; methylamine; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane;
DOI:10.1021/ol200971z

Reference yield:

: 1306597-64-7
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

: 1306597-69-2
N6-benzoyl,N6-acetyl-9-[3-O-acetyl-(5-O-tert-butyldiphenylsilyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 7 steps

1: boron trichloride / dichloromethane / 4.5 h / -78 °C

2: dmap / pyridine / 4 h / 40 °C

3: pyridine / 16 h / 40 °C

4: methylamine / methanol; ethanol; dichloromethane / 0.5 h / 0 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

6: dmap / pyridine / 48 h / 50 °C

7: 16 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; boron trichloride; methylamine; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane;
DOI:10.1021/ol200971z