N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Base Information

Chemical Name:N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine
CAS No.:1306597-68-1
Molecular Formula:C₆₆H₇₇N₅O₁₅Si₂
Molecular Weight:1236.53
Hs Code.:

N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Synonyms:N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Suppliers and Price of N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

There total 5 articles about N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1306597-67-0
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1306597-68-1
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Guidance literature:: N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine; 4,4'-dimethoxytrityl chloride; In pyridine;

In pyridine; acetic anhydride;
DOI:10.1080/15257770.2014.984073

Reference yield:

: 1306597-64-7
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

: 1306597-68-1
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 3 steps

1: boron trichloride / dichloromethane / 4.5 h / -78 °C

2: dmap / pyridine / 4 h / 40 °C

3: pyridine / 16 h / 40 °C

With dmap; boron trichloride; In pyridine; dichloromethane;
DOI:10.1021/ol200971z

Reference yield:

: 1306597-67-0
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

: 1306597-68-1
N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(5-O-dimethoxytrityl-2,3-di-O-acetyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / pyridine / 4 h / 40 °C

2: pyridine / 16 h / 40 °C

With dmap; In pyridine;
DOI:10.1021/ol200971z