(2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate

Base Information

• Chemical Name: (2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate
• CAS No.: 133963-99-2
• Molecular Formula: C₁₃H₁₈O₃S
• Molecular Weight: 254.35
• Mol file: 133963-99-2.mol

Synonyms:(2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate

Chemical Property of (2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate

There total 2 articles about (2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(Z)-1-ethylthio-1-(trimethylsiloxy)propene (63584-42-9,130535-66-9,63584-50-9) + 4-methoxy-benzaldehyde (123-11-5) → (2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate (133963-99-2)

Guidance literature:

With tin(II) trifluoromethanesulfonate; dibutyltin diacetate; (2S)-1-methyl-2-<(N-1-naphthylamino)methyl>pyrrolidine; In dichloromethane; at -78 ℃;

DOI:10.1021/ja00011a030

Reference yield:

(Z)-1-ethylthio-1-(trimethylsiloxy)propene (63584-42-9,130535-66-9,63584-50-9) + 4-methoxy-benzaldehyde (123-11-5) → (2S,3S)-S-ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanethioate (133963-99-2) + (2S,3R)-3-Hydroxy-3-(4-methoxy-phenyl)-2-methyl-thiopropionic acid S-ethyl ester + (2R,3S)-3-Hydroxy-3-(4-methoxy-phenyl)-2-methyl-thiopropionic acid S-ethyl ester

Guidance literature:

With borane; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 2.) THF;

DOI:10.1016/S0040-4039(00)91717-9

upstream raw materials:

(Z)-1-ethylthio-1-(trimethylsiloxy)propene

4-methoxy-benzaldehyde