1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

Base Information

Chemical Name:1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane
CAS No.:123330-88-1
Molecular Formula:C₂₀H₂₆N₂O₄
Molecular Weight:358.437
Hs Code.:

Synonyms:1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

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Chemical Property of 1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

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Technology Process of 1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

There total 7 articles about 1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 123330-87-0
1-<5-(tert-Butoxycarbonyl)-2-nitrophenoxy>-2-(5-methyl-2-nitrophenoxy)ethane

: 123330-88-1
1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 1h; Ambient temperature;
DOI:10.1021/ja00202a042

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 123330-88-1
1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pyridine; 2.) H₂O / 1.) 100 deg C, 30 min

2: SOCl₂, DMF / 0.25 h / Heating

3: pyridine / CHCl₃ / Heating

4: 45percent aq. KOH / methanol / 0.5 h

5: 92 percent / K₂CO₃, N-methylpyrrolidinone / 0.17 h / 140 °C

6: 81 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

With pyridine; 1-methyl-pyrrolidin-2-one; potassium hydroxide; thionyl chloride; water; hydrogen; potassium carbonate; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; chloroform; ethyl acetate;
DOI:10.1021/ja00202a042

Reference yield:

: 51257-24-0
3-Acetoxy-4-Nitrobenzoic Acid

: 123330-88-1
1-<2-Amino-5-(tert-butoxycarbonyl)phenoxy>-2-(2-amino-5-methylphenoxy)ethane

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂, DMF / 0.25 h / Heating

2: pyridine / CHCl₃ / Heating

3: 45percent aq. KOH / methanol / 0.5 h

4: 92 percent / K₂CO₃, N-methylpyrrolidinone / 0.17 h / 140 °C

5: 81 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

With pyridine; 1-methyl-pyrrolidin-2-one; potassium hydroxide; thionyl chloride; hydrogen; potassium carbonate; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; chloroform; ethyl acetate;
DOI:10.1021/ja00202a042