methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

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Chemical Name:methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate
CAS No.:930117-87-6
Molecular Formula:C₂₀H₃₀N₂O₃
Molecular Weight:346.47
Hs Code.:

Synonyms:methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

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Chemical Property of methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

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Technology Process of methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

There total 8 articles about methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₉NO₆S

: 766-17-6,1218906-26-3
(2R,6S)-2,6-dimethylpiperidine

: 7143-01-3
Methanesulfonic anhydride

: 930117-87-6
methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

Guidance literature:: C₁₄H₁₉NO₆S; (2R,6S)-2,6-dimethylpiperidine; Methanesulfonic anhydride; In dichloromethane; at 20 ℃;

With potassium carbonate; In dichloromethane; water;

Reference yield:

: C₁₄H₁₉NO₆S

: cis-2,6-dimethylpiperidine

: 930117-87-6
methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

Guidance literature:: With Methanesulfonic anhydride; In dichloromethane; at 20 ℃;
DOI:10.1021/op200129m

Reference yield:

: 930117-84-3
methyl (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoate

: 930117-87-6
methyl (2R)-2-acetylamino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]methyl}phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen / methanol / 5325.53 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.3 h / 25 °C

3: Methanesulfonic anhydride / dichloromethane / 20 °C

With (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride; In methanol; dichloromethane;
DOI:10.1021/op200129m