Technology Process of 5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-2,3,6-trimethoxytoluene
There total 12 articles about 5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-2,3,6-trimethoxytoluene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min
2: 1.) 1 M aq. Na2S2O4 (pH 7.0), 2.) Na2S2O4 / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min
3: K2CO3 / various solvent(s) / 1.5 h / Heating
4: various solvent(s) / 41 h
5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature
6: 96 percent / H2 / 5percent Pd/C / methanol / 42 h / 2585.7 Torr
7: barium hydroxide / dimethylformamide / 5 h
With
barium dihydroxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min
2: 1.) 1 M aq. Na2S2O4 (pH 7.0), 2.) Na2S2O4 / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min
3: K2CO3 / various solvent(s) / 1.5 h / Heating
4: various solvent(s) / 41 h
5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature
6: 96 percent / H2 / 5percent Pd/C / methanol / 42 h / 2585.7 Torr
7: barium hydroxide / dimethylformamide / 5 h
With
barium dihydroxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) 1 M aq. Na2S2O4 (pH 7.0), 2.) Na2S2O4 / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min
2: K2CO3 / various solvent(s) / 1.5 h / Heating
3: various solvent(s) / 41 h
4: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature
5: 96 percent / H2 / 5percent Pd/C / methanol / 42 h / 2585.7 Torr
6: barium hydroxide / dimethylformamide / 5 h
With
barium dihydroxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034
