2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

Base Information

Chemical Name:2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide
CAS No.:1621342-97-9
Molecular Formula:C₃₇H₃₆FN₃O₃
Molecular Weight:589.71
Hs Code.:

Synonyms:2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

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Chemical Property of 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

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Technology Process of 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

There total 5 articles about 2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 19841-73-7
4-(Diphenylmethyl)piperidine

: 1621341-92-1
2-bromo-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

: 1621342-97-9
2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

Guidance literature:: With potassium carbonate; potassium iodide; In acetone; for 24h; Reflux;
DOI:10.1016/j.ejmech.2014.06.024

Reference yield:

: 85-44-9
phthalic anhydride

: 1621342-97-9
2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / toluene / 24 h / Reflux

2: N-Bromosuccinimide; hydrogen bromide; thionyl chloride / tetrachloromethane / 8 h / Reflux

3: thionyl chloride / 3 h / Reflux

4: tetrahydrofuran / 72 h / 20 °C / Cooling with ice

5: potassium iodide; potassium carbonate / acetone / 24 h / Reflux

With N-Bromosuccinimide; thionyl chloride; hydrogen bromide; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; tetrachloromethane; acetone; toluene;
DOI:10.1016/j.ejmech.2014.06.024

Reference yield:

: 3130-75-4
4-phthalimidobutyric acid

: 1621342-97-9
2-(4-benzhydrylpiperidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorobenzyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; hydrogen bromide; thionyl chloride / tetrachloromethane / 8 h / Reflux

2: thionyl chloride / 3 h / Reflux

3: tetrahydrofuran / 72 h / 20 °C / Cooling with ice

4: potassium iodide; potassium carbonate / acetone / 24 h / Reflux

With N-Bromosuccinimide; thionyl chloride; hydrogen bromide; potassium carbonate; potassium iodide; In tetrahydrofuran; tetrachloromethane; acetone;
DOI:10.1016/j.ejmech.2014.06.024