3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

Base Information

Chemical Name:3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine
CAS No.:1174674-56-6
Molecular Formula:C₁₈H₂₂ClN₃O
Molecular Weight:331.845
Hs Code.:

Synonyms:3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

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Chemical Property of 3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

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Technology Process of 3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

There total 4 articles about 3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-30-0
3,6-dichlorpyridazine

: 1174675-06-9
(R)-2-methyl-1-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl}-pyrrolidine hydrochloride

: 1174674-56-6
3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

Guidance literature:: 3,6-dichlorpyridazine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; for 0.333333h;

(R)-2-methyl-1-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl}-pyrrolidine hydrochloride; With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; at 80 ℃; for 15h;

Reference yield: 90.0%

: 141-30-0
3,6-dichlorpyridazine

: 1005403-35-9
(R)-2-methyl-1-{3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxyl]propyl}pyrrolidine

: 1174674-56-6
3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

Guidance literature:: With palladium diacetate; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; ethanol; water; at 80 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm200401v

Reference yield:

: 889865-32-1
2-[4-(3-chloropropoxy)phenyl]-4,4,5,5,-tetramethyl[1,3,2]dioxaborolane

: 1174674-56-6
3-chloro-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / acetonitrile / 60 h / Reflux

2: palladium diacetate; sodium hydrogencarbonate; triphenylphosphine / tetrahydrofuran; ethanol; water / 15 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; sodium iodide; In tetrahydrofuran; ethanol; water; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm200401v