N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide

Base Information

• Chemical Name: N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide
• CAS No.: 342634-60-0
• Molecular Formula: C₅₀H₆₅N₃O₄
• Molecular Weight: 772.084
• Mol file: 342634-60-0.mol

Synonyms:N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide

Chemical Property of N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide

There total 2 articles about N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-((2,2-diphenylethyl)amino)-4-oxobutanoic acid (137379-56-7) + 2-(12-aminododecyl)-5,8-di-tert-butylbenzo[de]isoquinoline-1,3-dione → N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide (342634-60-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ja0352552

Reference yield:

2,2-Diphenylethylamine (3963-62-0) → N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide (342634-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridine / 16 h

2: 98 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 12 h / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1021/ja0352552

Reference yield: 59.0%

p-xylylidenediamine (539-48-0) + benzene-1,3-dicarbonyl dichloride (99-63-8) + N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)-succinamide (342634-60-0) → [2]-(1,4,7,14,17,20-hexaaza-2,6,15,19-tetraoxo-3,5,9,12,16,18,22,25-tetrabenzocyclohexacosane)-(N-{12-[5,8-di(tert-butyl)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]dodecyl}-N'-(2,2-diphenylethyl)succinamide)-rotaxane

Guidance literature:

With triethylamine; In chloroform; for 4h;

DOI:10.1021/ja0352552

upstream raw materials:

4-((2,2-diphenylethyl)amino)-4-oxobutanoic acid

2,2-Diphenylethylamine