4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid

Base Information

• Chemical Name: 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid
• CAS No.: 150618-07-8
• Molecular Formula: C₂₂H₂₅NO₆
• Molecular Weight: 399.444

Synonyms:4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid

Chemical Property of 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid

There total 4 articles about 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester (150618-06-7) → 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid (150618-07-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0960-894X(01)00269-4

Reference yield:

N-tert.-butoxycarbonyl-(4-trifluoromethanesulfonyloxy)-L-phenylalanine benzyl ester (123993-20-4) → 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid (150618-07-8)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; In dimethyl sulfoxide; at 65 ℃;

DOI:10.1039/a903449h

Reference yield:

N-tert-butoxycarbonyl-L-tyrosine benzyl ester (19391-35-6) → 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid (150618-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂

2: KOAc; Ph₂P(CH₂)3PPh₂ / Pd(OAc)2 / dimethylsulfoxide / 65 °C

With pyridine; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; In dichloromethane; dimethyl sulfoxide; 1: Esterification / 2: Carbonylation;

DOI:10.1039/a903449h

upstream raw materials:

4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

N-tert.-butoxycarbonyl-(4-trifluoromethanesulfonyloxy)-L-phenylalanine benzyl ester

N-tert-butoxycarbonyl-L-tyrosine benzyl ester

Downstream raw materials:

(S)-2-tert-Butoxycarbonylamino-3-(4-chlorocarbonyl-phenyl)-propionic acid benzyl ester

(S)-4-[4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoylamino]-4-(6-{(S)-2-[4-((S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoylamino]-4-methoxycarbonyl-butyrylamino}-pyridin-2-ylcarbamoyl)-butyric acid methyl ester

3-[4-(2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-phenyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester

(S)-4-{(S)-2-Acetylamino-3-[4-(2-methoxycarbonyl-2-oxo-acetyl)-phenyl]-propionylamino}-4-[(1S,2R)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-butyric acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150618-07-8 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send