ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate

Base Information

• Chemical Name: ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate
• CAS No.: 1308815-00-0
• Molecular Formula: C₂₃H₂₄N₂O₅
• Molecular Weight: 408.454
• Mol file: 1308815-00-0.mol

Synonyms:ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate

Chemical Property of ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate

There total 5 articles about ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

ethyl 1-(4-aminophenyl)cyclopropanecarboxylate (1308814-99-4) + 2-oxiranylmethylisoindole-1,3-dione (5455-98-1) → ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate (1308815-00-0)

Guidance literature:

In ethanol; at 80 ℃; for 15h;

Reference yield:

phenylacetonitrile (140-29-4) → ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate (1308815-00-0)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium hydroxide; tetrabutylammomium bromide / water / 1 h / 50 °C

2: sodium nitrate; sulfuric acid / 0 - 20 °C

3: sulfuric acid / 10 h / 26 °C / Reflux

4: tin(II) chloride hydrate / ethyl acetate / 4 h / 25 - 75 °C

5: ethanol / 15 h / 80 °C

With sodium nitrate; tin(II) chloride hydrate; sulfuric acid; tetrabutylammomium bromide; potassium hydroxide; In ethanol; water; ethyl acetate;

Reference yield:

1-(4-nitrophenyl)-1-cyclopropylcarbonitrile (408328-42-7) → ethyl 1-(4-((3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropyl)amino)phenyl)cyclopropanecarboxylate (1308815-00-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 10 h / 26 °C / Reflux

2: tin(II) chloride hydrate / ethyl acetate / 4 h / 25 - 75 °C

3: ethanol / 15 h / 80 °C

With tin(II) chloride hydrate; sulfuric acid; In ethanol; ethyl acetate;

upstream raw materials:

phenylacetonitrile

1-cyano-1-phenylcyclopropane

ethyl 1-(4-aminophenyl)cyclopropanecarboxylate

2-oxiranylmethylisoindole-1,3-dione

Downstream raw materials:

ethyl 1-(4-(5-((1,3-dioxoisoindolin-2-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)cyclopropanecarboxylate

ethyl 1-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)cyclopropanecarboxylate

ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate

5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide