5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Base Information

Chemical Name:5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS No.:1308815-08-8
Molecular Formula:C₁₉H₁₉ClN₂O₄S
Molecular Weight:406.89
Hs Code.:

Synonyms:5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

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Chemical Property of 5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

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Technology Process of 5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

There total 11 articles about 5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1308815-04-4
ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate

: 1308815-08-8
5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate; With lithium borohydride; In tetrahydrofuran; at 40 - 45 ℃; for 15h;

With hydrogenchloride; water;

Reference yield:

: 408328-42-7
1-(4-nitrophenyl)-1-cyclopropylcarbonitrile

: 1308815-08-8
5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 10 h / 26 °C / Reflux

2: tin(II) chloride hydrate / ethyl acetate / 4 h / 25 - 75 °C

3: ethanol / 15 h / 80 °C

4: chloroform / 3 h / 65 °C

5: methylamine / water; tetrahydrofuran / 15 h / 10 - 30 °C

6: pyridine / dichloromethane / 4 h / 10 - 30 °C

7: lithium borohydride / tetrahydrofuran / 15 h / 40 - 45 °C

With pyridine; lithium borohydride; tin(II) chloride hydrate; sulfuric acid; methylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; ethyl acetate;

Reference yield:

: 1308814-99-4
ethyl 1-(4-aminophenyl)cyclopropanecarboxylate

: 1308815-08-8
5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 15 h / 80 °C

2: chloroform / 3 h / 65 °C

3: methylamine / water; tetrahydrofuran / 15 h / 10 - 30 °C

4: pyridine / dichloromethane / 4 h / 10 - 30 °C

5: lithium borohydride / tetrahydrofuran / 15 h / 40 - 45 °C

With pyridine; lithium borohydride; methylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water;