5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Base Information

Chemical Name:5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS No.:1308814-51-8
Molecular Formula:C₂₁H₂₄ClN₃O₃S
Molecular Weight:433.959
Hs Code.:

Synonyms:5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

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Chemical Property of 5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

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Technology Process of 5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

There total 13 articles about 5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1308815-09-9
N-((3-(4-(1-(bromomethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)-5-chlorothiophene-2-carboxamide

: 124-40-3
dimethyl amine

: 1308814-51-8
5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: In tetrahydrofuran; water; at 25 - 30 ℃; for 4h;

Reference yield:

: 408328-42-7
1-(4-nitrophenyl)-1-cyclopropylcarbonitrile

: 1308814-51-8
5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid / 10 h / 26 °C / Reflux

2: tin(II) chloride hydrate / ethyl acetate / 4 h / 25 - 75 °C

3: ethanol / 15 h / 80 °C

4: chloroform / 3 h / 65 °C

5: methylamine / water; tetrahydrofuran / 15 h / 10 - 30 °C

6: pyridine / dichloromethane / 4 h / 10 - 30 °C

7: lithium borohydride / tetrahydrofuran / 15 h / 40 - 45 °C

8: carbon tetrabromide; triphenylphosphine / dichloromethane / 4 h / 10 - 45 °C

9: water; tetrahydrofuran / 4 h / 25 - 30 °C

With pyridine; lithium borohydride; tin(II) chloride hydrate; carbon tetrabromide; sulfuric acid; triphenylphosphine; methylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; ethyl acetate;

Reference yield:

: 1308814-99-4
ethyl 1-(4-aminophenyl)cyclopropanecarboxylate

: 1308814-51-8
5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 15 h / 80 °C

2: chloroform / 3 h / 65 °C

3: methylamine / water; tetrahydrofuran / 15 h / 10 - 30 °C

4: pyridine / dichloromethane / 4 h / 10 - 30 °C

5: lithium borohydride / tetrahydrofuran / 15 h / 40 - 45 °C

6: carbon tetrabromide; triphenylphosphine / dichloromethane / 4 h / 10 - 45 °C

7: water; tetrahydrofuran / 4 h / 25 - 30 °C

With pyridine; lithium borohydride; carbon tetrabromide; triphenylphosphine; methylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water;