[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine

Base Information

Chemical Name:[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
CAS No.:85381-24-4
Molecular Formula:C₄₃H₃₉ClN₃O₁₀P.C₆H₁₅N
Molecular Weight:925.415
Hs Code.:
European Community (EC) Number:286-752-2

[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine

Synonyms:EINECS 286-752-2;85381-24-4

Suppliers and Price of [(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of [(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:18
Exact Mass:924.3266086
Heavy Atom Count:65
Complexity:1480

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC.COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CC(O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)OP(=O)(O)OC7=CC=CC=C7Cl
Isomeric SMILES:CCN(CC)CC.COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H](C[C@@H](O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)OP(=O)(O)OC7=CC=CC=C7Cl

Technology Process of [(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine

There total 1 articles about [(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl] (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15715-58-9
triethylamine carbonate

: 67219-55-0
4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 85381-24-4
5'-O-(dimethoxytrityl)-N-benzoyl-2'-deoxycytidine 3'-(o-chlorophenyl) phosphate triethylammonium salt

Guidance literature:: 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine; 2-chlorophenyl dichlorophosphate; With pyridine; 1,2,3-triazole; In dichloromethane; at 0 ℃; for 2.5h;

triethylamine carbonate; With water; In dichloromethane; Further stages.;
DOI:10.1080/15257770701426260

Reference yield: 83.0%

: 85381-24-4
5'-O-(dimethoxytrityl)-N-benzoyl-2'-deoxycytidine 3'-(o-chlorophenyl) phosphate triethylammonium salt

: 80817-38-5
N⁴-benzoyl-2'-deoxycytidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate

: 75251-87-5
N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxycytidylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester

Guidance literature:: With 1-methyl-1H-imidazole; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In pyridine; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)98833-6

Reference yield: 77.0%

: 85381-24-4
5'-O-(dimethoxytrityl)-N-benzoyl-2'-deoxycytidine 3'-(o-chlorophenyl) phosphate triethylammonium salt

: 63660-23-1
3'-O-benzoyl-N²-isobutyryl-2'-deoxyguanosine

: 99388-91-7
C₆₄H₆₀ClN₈O₁₅P

Guidance literature:: With 1-methyl-1H-imidazole; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In pyridine; for 0.5h;
DOI:10.1016/S0040-4039(00)98833-6