2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

Base Information

Chemical Name:2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol
CAS No.:878014-52-9
Molecular Formula:C₂₆H₂₁ClFN₅O₂S
Molecular Weight:522.002
Hs Code.:

Synonyms:2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

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Chemical Property of 2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

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Technology Process of 2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

There total 7 articles about 2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: C₃₃H₃₈ClFN₆O₄S

: 878014-52-9
2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

Guidance literature:: C₃₃H₃₈ClFN₆O₄S; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 12.25h;

With sodium hydroxide; In water; pH=10; Product distribution / selectivity;

Reference yield:

: 202197-26-0
3-chloro-4-(3-fluorobenzyloxy)aniline

: 878014-52-9
2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,4-dioxane; isopropyl alcohol / 15 h / 80 °C

2.1: water; acetic acid / 16 h / 80 °C

2.2: 0.17 h / 20 °C

3.1: toluene / 4 h / 70 °C

4.1: ethanol / 24.08 h / Heating / reflux

4.2: 12.25 h / 0 - 20 °C

4.3: pH 10

With water; acetic acid; In 1,4-dioxane; ethanol; isopropyl alcohol; toluene;

Reference yield:

: 443882-99-3
3-chloro-4-(3-fluorobenzyloxy)nitrobenzene

: 878014-52-9
2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; acetic acid / ethyl acetate / 20 °C

2.1: 1,4-dioxane; isopropyl alcohol / 15 h / 80 °C

3.1: water; acetic acid / 16 h / 80 °C

3.2: 0.17 h / 20 °C

4.1: toluene / 4 h / 70 °C

5.1: ethanol / 24.08 h / Heating / reflux

5.2: 12.25 h / 0 - 20 °C

5.3: pH 10

With water; iron; acetic acid; In 1,4-dioxane; ethanol; ethyl acetate; isopropyl alcohol; toluene;