2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate

Base Information

• Chemical Name: 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate
• CAS No.: 878014-29-0
• Molecular Formula: C₂₇H₂₃ClFN₅O₄S₂
• Molecular Weight: 600.094

Synonyms:2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate

Chemical Property of 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate

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Technology Process of 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate

There total 2 articles about 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol (878014-28-9) + Methanesulfonic anhydride (7143-01-3) → 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate (878014-29-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 6h; Product distribution / selectivity;

Reference yield:

2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol (878014-52-9) + 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol (878014-28-9) + Methanesulfonic anhydride (7143-01-3) → 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate (878014-29-0) + 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethyl methanesulfonate

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h; Product distribution / selectivity;

Reference yield: 55.0%

1-methyl-piperazine (109-01-3) + 2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethylmethanesulfonate (878014-29-0) → N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-2-[2-(4-methylpiperazin-1-yl)ethyl]-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-6-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 15h; Heating / reflux;

upstream raw materials:

2-[6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-4,5-dihydro-3H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-3-yl]ethanol

2-[6-({3-chloro-4-[(3-fluoro-benzyl)oxy]-phenyl}amino)-4,5-dihydro-2H-pyrimido[5',4':4,5]thieno[2,3-e]indazol-2-yl]ethanol

Methanesulfonic anhydride

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