(4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Base Information

Chemical Name:(4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone
CAS No.:1443760-57-3
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:(4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

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Chemical Property of (4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Chemical Property:

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Technology Process of (4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

There total 4 articles about (4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443760-55-1
1-benzyl-2-methoxymethyl-2-methyl-piperazine

: 26893-73-2
6-methoxypyridine-2-carboxylic acid

: 1443760-57-3
(4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1443760-51-7
[benzyl-(1-cyano-2-methoxy-1-methyl-ethyl)-amino]-acetic acid ethyl ester

: 1443760-57-3
(4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; cobalt(II) chloride; sodium tetrahydroborate / 20 °C / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

With methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; cobalt(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 1443760-57-3
(4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 0.5 h / 80 °C

2: methanol; cobalt(II) chloride; sodium tetrahydroborate / 20 °C / Cooling with ice

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

With methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; cobalt(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;