6-Methoxypyridine-2-carboxylic acid

Base Information

• Chemical Name: 6-Methoxypyridine-2-carboxylic acid
• CAS No.: 26893-73-2
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 29333990
• European Community (EC) Number: 626-873-3
• DSSTox Substance ID: DTXSID60341188
• Nikkaji Number: J100.093D
• Wikidata: Q72485788
• Mol file: 26893-73-2.mol

Synonyms:26893-73-2;6-Methoxypicolinic acid;6-Methoxypyridine-2-carboxylic acid;6-Methoxy-2-pyridinecarboxylic acid;2-methoxy-6-picolinic acid;2-Pyridinecarboxylic acid, 6-methoxy-;2-Methoxy-6-picolinicacid;Picolinic acid, 6-methoxy-;MFCD06800962;6-Methoxy-pyridine-2-carboxylic acid;6-Methoxypicolinicacid;6-Methoxy Picolinic Acid;SCHEMBL17338;DTXSID60341188;CS-D1581;WAA07865;BBL101244;CL0063;STL555040;AKOS005257711;AB29993;AC-7514;6-(methyloxy)-2-pyridinecarboxylic acid;SY007551;TS-02030;6-Methoxypyridine-2-carboxylic acid, 97%;2-METHOXY-6-PYRIDINECARBOXYLIC ACID;A5273;AM20061706;FT-0638647;FT-0650038;M2189;EN300-102850;J-016589;J-513171;4-((5-(tributylstannyl)pyridin-2-yl)methyl)morpholine;Z969095262

Chemical Property of 6-Methoxypyridine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.015mmHg at 25°C
• Melting Point: 38.5-39.5 °C
• Refractive Index: 1.504
• Boiling Point: 300.8 °C at 760 mmHg
• PKA: 3.52±0.10(Predicted)
• Flash Point: 135.7 °C
• PSA: 59.42000
• Density: 1.284 g/cm³
• LogP: 0.78840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxypicolinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=N1)C(=O)O
• Uses: It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of 6-Methoxypyridine-2-carboxylic acid

There total 2 articles about 6-Methoxypyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-Hydroxypicolinic acid (19621-92-2) + methyl iodide (74-88-4) → 6-methoxypyridine-2-carboxylic acid (26893-73-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water; toluene;

Reference yield:

→ 6-methoxypyridine-2-carboxylic acid (26893-73-2)

Guidance literature:

6-Brom-picolinsaeure, Na/Me.;

Reference yield: 87.0%

2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate (1443758-97-1) + 6-methoxypyridine-2-carboxylic acid (26893-73-2) → 4-(6-methoxy-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester (1443759-06-5)

Guidance literature:

6-methoxypyridine-2-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

6-Hydroxypicolinic acid

methyl iodide

Downstream raw materials:

C₃₁H₃₉BN₄O₈

2-(bromomethyl)-6-methoxypyridine

(6-methoxy-pyridin-2-yl)-methanol

1,1,1,3,3,3-hexafluoro-2-(4-(2-((6-methoxy-2-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol