(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

Base Information

Chemical Name:(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid
CAS No.:1316645-32-5
Molecular Formula:C₁₁H₁₇NO₈P₂
Molecular Weight:353.205
Hs Code.:

Synonyms:(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

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Chemical Property of (2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

Chemical Property:

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Technology Process of (2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

There total 11 articles about (2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1315613-53-6
(2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-phenylbutanoate

: 1316645-32-5
(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja2043563

Reference yield:

: 100-52-7
benzaldehyde

: 1316645-32-5
(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; titanium tetrachloride / tetrahydrofuran; tetrachloromethane / 1 h / 0 °C

2: (R)-TF-Biphamphos; potassium carbonate; tetrakis(acetonitrile)copper(I) tetrafluoroborate / dichloromethane / 48 h / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / diethyl ether; water / 20 °C

4: trimethylsilyl iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; trimethylsilyl iodide; (R)-TF-Biphamphos; titanium tetrachloride; potassium carbonate; toluene-4-sulfonic acid; tetrakis(acetonitrile)copper(I) tetrafluoroborate; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile; 2: Michael addition;
DOI:10.1021/ja2043563

Reference yield:

: C₂₇H₃₉NO₉P₂

: 1316645-32-5
(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / diethyl ether; water / 20 °C

2: trimethylsilyl iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

With trimethylsilyl iodide; toluene-4-sulfonic acid; In diethyl ether; water; acetonitrile;
DOI:10.1021/ja2043563