(2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

Base Information

Chemical Name:(2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate
CAS No.:1316645-34-7
Molecular Formula:C₁₇H₂₉NO₈P₂
Molecular Weight:437.367
Hs Code.:

Synonyms:(2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

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Chemical Property of (2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

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Technology Process of (2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

There total 12 articles about (2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1316645-32-5
(2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 1316645-34-7
(2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

Guidance literature:: With methanol; In hexane; at 20 ℃; for 0.25h;
DOI:10.1021/ja2043563

Reference yield:

: 100-52-7
benzaldehyde

: 1316645-34-7
(2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; titanium tetrachloride / tetrahydrofuran; tetrachloromethane / 1 h / 0 °C

2: (R)-TF-Biphamphos; potassium carbonate; tetrakis(acetonitrile)copper(I) tetrafluoroborate / dichloromethane / 48 h / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / diethyl ether; water / 20 °C

4: trimethylsilyl iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

5: methanol / hexane / 0.25 h / 20 °C

With 4-methyl-morpholine; methanol; trimethylsilyl iodide; (R)-TF-Biphamphos; titanium tetrachloride; potassium carbonate; toluene-4-sulfonic acid; tetrakis(acetonitrile)copper(I) tetrafluoroborate; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; acetonitrile; 2: Michael addition;
DOI:10.1021/ja2043563

Reference yield:

: C₂₆H₃₆BrNO₈P₂

: 1316645-34-7
(2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / diethyl ether; water / 20 °C

2: trimethylsilyl iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

3: methanol / hexane / 0.25 h / 20 °C

With methanol; trimethylsilyl iodide; toluene-4-sulfonic acid; In diethyl ether; hexane; water; acetonitrile;
DOI:10.1021/ja2043563