(S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

Base Information

Chemical Name:(S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester
CAS No.:911697-22-8
Molecular Formula:C₁₆H₁₉N₃O₄
Molecular Weight:317.345
Hs Code.:

Synonyms:(S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

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Chemical Property of (S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

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Technology Process of (S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

There total 8 articles about (S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 151-50-8
potassium cyanide

: 154342-89-9
(2S)-ethyl N¹-benzyl-4-oxopyrrolidine-2-carboxylate

: 911697-22-8
(S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

Guidance literature:: With ammonium carbonate; In ethanol; water; at 50 - 55 ℃; for 20h;

Reference yield:

: 103667-57-8
(2S,4R)-ethyl N¹-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate

: 911697-22-8
(S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Pd/C / ethanol / 2.5 h / 3102.9 Torr / Ambient temperature

2: i-Pr₂NEt / ethanol / Ambient temperature

3: 94 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 2 h / -78 °C

4: ethanol; H₂O / 55 °C

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1021/jm9601765

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 911697-22-8
(S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / Et₃N / acetonitrile / 55 °C

2: H₂ / 5percent Pd/C / ethanol / 2.5 h / 3102.9 Torr / Ambient temperature

3: i-Pr₂NEt / ethanol / Ambient temperature

4: 94 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 2 h / -78 °C

5: ethanol; H₂O / 55 °C

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm9601765