154342-89-9

Upstream product

• 154342-88-8 (2S,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 100-44-7 benzyl chloride 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 103667-57-8 (2S,4R)-ethyl N¹-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate 
• 61478-25-9 (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid ethyl ester 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 154342-34-4 (2S,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin 
• 154429-28-4 (2S,4S)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin 
• 911697-22-8 (S)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester 
• 911697-27-3 (2S,4R)-1-Benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 911697-26-2 (2S,4S)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 171336-82-6 methyl (2S,4R)-4-amino-1-benzyl-4-methoxycarbonylprolinate 
• 171192-78-2 methyl (2S,4S)-4-amino-1-benzyl-4-methoxycarbonylprolinate 
• 171336-79-1 (2S,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid 
• 171336-79-1 (2S,4S)-4-amino-4-carboxyproline 
• 178963-37-6 (2S,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 178963-36-5 (2S,4S)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 179030-58-1 (2S,4R)-1-Benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 179030-56-9 (2S,4S)-1-Benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 171336-77-9 (2S,4R)-4-amino-1-benzyl-4-carboxyproline 

Relevant academic research and scientific papers

Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): Identification of a new group III metabotropic glutamate receptor selective agonist

A new family of mGlu receptor orthosteric ligands called APTCs was designed and synthesized using a parallel chemistry approach. Amongst 65 molecules tested on mGlu4, mGlu6 and mGlu8 subtypes, (2S,4S)-4-amino-1-[(E)-3-carboxyacryloyl]pyrrolidine-2,4-dicar

TRANS PYRROLIDINYL DERIVATIVES AND THEIR PHARMACEUTICAL USE

The present invention relates to the use of trans pyrrolidinyl of the formula (I) or (II) in which: R1, R2or R3 are hydrogen or a carboxy or amino protecting group; R4 to R8 represent hydrogen or an a

Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: Identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase

The four isomers of 4-aminopyrrolidine-2,4-dicarboxylate (APDC) were prepared and evaluated for their effects at glutamate receptors in vitro. (2R,4R)-APDC (2a), an aza analog of the nonselective mGluR agonist (1S,3R)- 1-aminocyclopentane-1,3-dicarboxylat

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyproline: Novel conformationally restricted glutamic acid analogues

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyprolines, i.e. (2S,4S)-3, (2S,4R)-4, and their corresponding enantiomers, as novel conformationally restricted analogues of glutamic acid, were performed from trans-4-hydroxy-L-proline as a homochiral starting material. The key step was the spirohydantoin ring formation by employing the Bucherer-Bergs reaction of 4-oxoproline derivatives. These structures were determined by NMR studies.