5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

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Chemical Name:5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid
CAS No.:1383816-94-1
Molecular Formula:C₃₀H₃₀F₃N₃O₅
Molecular Weight:569.581
Hs Code.:

Synonyms:5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

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Chemical Property of 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

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Technology Process of 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

There total 10 articles about 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383816-93-0
methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

: 1383816-94-1
5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

Guidance literature:: methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate; With water; potassium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 2h;

With acetic acid; In tetrahydrofuran; methanol; water; pH=6;

Reference yield:

: 946427-86-7
4-(bromomethyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole

: 1383816-94-1
5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; microwave irradiation

5.1: water; potassium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

5.2: pH 6

With 18-crown-6 ether; potassium tert-butylate; water; caesium carbonate; trifluoroacetic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 1383740-01-9
(Z)-N-hydroxy-2-(trifluoromethoxy)benzimidoyl chloride

: 1383816-94-1
5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / tetrahydrofuran / 6 h / -10 - 35 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

4.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; microwave irradiation

8.1: water; potassium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

8.2: pH 6

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; water; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE;