methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

Base Information

Chemical Name:methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate
CAS No.:1383816-93-0
Molecular Formula:C₃₁H₃₂F₃N₃O₅
Molecular Weight:583.607
Hs Code.:

Synonyms:methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

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Chemical Property of methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

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Technology Process of methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

There total 9 articles about methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: bromo(cyclopropyl)zinc

: 1383816-92-9
methyl 5-bromo-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

: 1383816-93-0
methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Inert atmosphere; microwave irradiation;

Reference yield:

: 1383740-01-9
(Z)-N-hydroxy-2-(trifluoromethoxy)benzimidoyl chloride

: 1383816-93-0
methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / tetrahydrofuran / 6 h / -10 - 35 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

4: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; microwave irradiation

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 1103500-32-8
methyl 5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate

: 1383816-93-0
methyl 5-cyclopropyl-6-((1S,3R)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)nicotinate

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

3: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; microwave irradiation

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;