2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

Base Information

Chemical Name:2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate
CAS No.:291536-99-7
Molecular Formula:C₂₃H₁₈Cl₂INO₄S
Molecular Weight:602.277
Hs Code.:

Synonyms:2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

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Chemical Property of 2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

Chemical Property:

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Technology Process of 2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

There total 9 articles about 2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 478316-27-7
2,4-dichloro-6-[2-(2-iodophenyl)-2-oxo-ethyl]phenyl benzenesulfonate

: 291536-99-7
2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

Guidance literature:: In toluene; at 90 ℃;
DOI:10.1021/jo025767j

Reference yield:

: 26260-02-6
2-iodobenzaldehyde

: 291536-99-7
2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / H₂O; acetonitrile / 20 °C

2.1: NaH / dimethylformamide / -19 °C

2.2: dimethylformamide / -19 - 20 °C

3.1: 83 percent / conc. HCl / methanol; H₂O / 90 °C

4.1: 41 percent / toluene / 90 °C

With hydrogenchloride; sodium hydride; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 291536-99-7
2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 74 percent / pyridine / 2 h / 80 °C

2.1: 99 percent / LAH / tetrahydrofuran / -19 °C

3.1: CBr₄ / CH₂Cl₂ / 0.17 h / 20 °C

3.2: 68 percent / PPh₃ / CH₂Cl₂ / 1.5 h / 0 °C

4.1: NaH / dimethylformamide / -19 °C

4.2: dimethylformamide / -19 - 20 °C

5.1: 83 percent / conc. HCl / methanol; H₂O / 90 °C

6.1: 41 percent / toluene / 90 °C

With hydrogenchloride; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j