2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

Base Information

Chemical Name:2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate
CAS No.:291537-07-0
Molecular Formula:C₂₇H₁₇Cl₂IN₂O₃S
Molecular Weight:647.32
Hs Code.:

Synonyms:2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

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Chemical Property of 2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

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Technology Process of 2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

There total 10 articles about 2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 59-88-1
phenylhydrazine hydrochloride

: 291536-99-7
2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate

: 291537-07-0
2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

Guidance literature:: With sodium carbonate; acetic acid; In methanol; water; at 145 ℃; pH=4;
DOI:10.1021/jo025767j

Reference yield:

: 26260-02-6
2-iodobenzaldehyde

: 291537-07-0
2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / H₂O; acetonitrile / 20 °C

2.1: NaH / dimethylformamide / -19 °C

2.2: dimethylformamide / -19 - 20 °C

3.1: 83 percent / conc. HCl / methanol; H₂O / 90 °C

4.1: 41 percent / toluene / 90 °C

5.1: 12 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With hydrogenchloride; sodium hydride; sodium carbonate; acetic acid; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 291537-07-0
2,4-dichloro-6-[5-(2-iodophenyl)-1-phenyl-1H-pyrazol-4-yl]phenyl benzenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 74 percent / pyridine / 2 h / 80 °C

2.1: 99 percent / LAH / tetrahydrofuran / -19 °C

3.1: CBr₄ / CH₂Cl₂ / 0.17 h / 20 °C

3.2: 68 percent / PPh₃ / CH₂Cl₂ / 1.5 h / 0 °C

4.1: NaH / dimethylformamide / -19 °C

4.2: dimethylformamide / -19 - 20 °C

5.1: 83 percent / conc. HCl / methanol; H₂O / 90 °C

6.1: 41 percent / toluene / 90 °C

7.1: 12 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With hydrogenchloride; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; sodium carbonate; acetic acid; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j