(4S)-4-azaniumyl-5-(naphthalen-2-ylamino)-5-oxopentanoate

Base Information

• Chemical Name: (4S)-4-azaniumyl-5-(naphthalen-2-ylamino)-5-oxopentanoate
• CAS No.: 635-86-9
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.304
• Mol file: 635-86-9.mol

Synonyms:

Chemical Property of (4S)-4-azaniumyl-5-(naphthalen-2-ylamino)-5-oxopentanoate

Chemical Property:

• Vapor Pressure: 8.42E-15mmHg at 25°C
• Melting Point: 174-175 °C
• Boiling Point: 590.7°C at 760 mmHg
• PKA: 4.24±0.10(Predicted)
• Flash Point: 311.1°C
• PSA: 92.42000
• Density: 1.329g/cm³
• LogP: 2.74370
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 272.11609238
• Heavy Atom Count: 20
• Complexity: 354

Purity/Quality:

99% ^*data from raw suppliers

H-Glu-βNA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)NC(=O)C(CCC(=O)[O-])[NH3+]
• Isomeric SMILES: C1=CC=C2C=C(C=CC2=C1)NC(=O)[C@H](CCC(=O)[O-])[NH3+]
• Uses: H-Glu-βNA and other aminoacyl-2-naphthylamides have been used as substrates for fluorimetric determination of aminopeptidases in human brain.

Technology Process of (4S)-4-azaniumyl-5-(naphthalen-2-ylamino)-5-oxopentanoate

There total 3 articles about (4S)-4-azaniumyl-5-(naphthalen-2-ylamino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-LLE-bNA (112982-92-0) → L-glutamic acid α-(β-naphthylamide) (635-86-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

naphthalen-2-ylamine (91-59-8) → L-glutamic acid α-(β-naphthylamide) (635-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: H₂, HCl / Pd-C / ethanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; toluene;

Reference yield:

N-(benzyloxycarbonyl)-L-glutamic acid anhydride (4124-76-9) → L-glutamic acid α-(β-naphthylamide) (635-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: H₂, HCl / Pd-C / ethanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; toluene;

upstream raw materials:

(Z)-LLE-bNA

naphthalen-2-ylamine

N-(benzyloxycarbonyl)-L-glutamic acid anhydride