1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

Base Information

Chemical Name:1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate
CAS No.:1555695-20-9
Molecular Formula:C₂HF₃O₂*C₂₉H₂₃F₅N₄O₃
Molecular Weight:684.543
Hs Code.:

Synonyms:1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

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Chemical Property of 1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

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Technology Process of 1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

There total 5 articles about 1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1555700-93-0
1-(2-(4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

: 76-05-1
trifluoroacetic acid

: 1555695-20-9
1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

Guidance literature:: 1-(2-(4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea; With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane; at -20 - 20 ℃; for 2h;

trifluoroacetic acid;

Reference yield:

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1555695-20-9
1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 110 °C / Inert atmosphere

2: zinc; ammonium chloride / dichloromethane; methanol / 0.33 h / 20 °C

3: dmap / dichloromethane / 1 h / 20 °C

4: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 2 h / -20 - 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; tetra-(n-butyl)ammonium iodide; ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 401816-16-8
(2,6-difluoropyridin-4-yl)boronic acid

: 1555695-20-9
1-(2-(4-(2,6-difluoropyridin-4-yl)-7-hydroxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 110 °C / Inert atmosphere

2: zinc; ammonium chloride / dichloromethane; methanol / 0.33 h / 20 °C

3: dmap / dichloromethane / 1 h / 20 °C

4: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 2 h / -20 - 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; tetra-(n-butyl)ammonium iodide; ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; methanol; dichloromethane;