4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

Base Information

Chemical Name:4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline
CAS No.:1555700-88-3
Molecular Formula:C₂₂H₁₉F₂N₃O₃
Molecular Weight:411.408
Hs Code.:

Synonyms:4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

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Chemical Property of 4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

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Technology Process of 4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

There total 1 articles about 4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 401816-16-8
(2,6-difluoropyridin-4-yl)boronic acid

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1555700-88-3
4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; at 110 ℃; for 5h; Inert atmosphere;

Reference yield: 96.0%

: 1555700-88-3
4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555700-90-7
2-(4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

Guidance literature:: With ammonium chloride; zinc; In methanol; dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

: 1555700-88-3
4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555700-93-0
1-(2-(4-(2,6-difluoropyridin-4-yl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; ammonium chloride / dichloromethane; methanol / 0.33 h / 20 °C

2: dmap / dichloromethane / 1 h / 20 °C

With dmap; ammonium chloride; zinc; In methanol; dichloromethane;