dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate

Base Information

• Chemical Name: dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate
• CAS No.: 1355235-82-3
• Molecular Formula: C₄₅H₃₉NO₁₁P₂
• Molecular Weight: 831.752
• Mol file: 1355235-82-3.mol

Synonyms:dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate

Chemical Property of dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate

There total 9 articles about dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one (1355235-81-2) → dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate (1355235-82-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

Reference yield: 74.0%

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxy-1H-quinolin-4-one (1355235-81-2) → dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate (1355235-82-3)

Guidance literature:

2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxy-1H-quinolin-4-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃;

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; In tetrahydrofuran; mineral oil; for 0.166667h;

DOI:10.3390/molecules18078028

Reference yield:

methyl 3-(benzyloxy)-5-methoxybenzoate (50637-26-8) → dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate (1355235-82-3)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydroxide; water / ethanol / 1 h / Reflux

2: N,N-dimethyl-formamide; thionyl chloride / toluene

3: triethylamine / tetrahydrofuran / 24 h / 20 °C

4: sodium hydroxide / 1,4-dioxane / 24 h / Reflux

5: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

6: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

With thionyl chloride; water; hydrogen; sodium hydride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; mineral oil;

upstream raw materials:

methyl 3-(benzyloxy)-5-methoxybenzoate

1-carbomethoxy-3,5-dihydroxybenzene

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxy-1H-quinolin-4-one

Downstream raw materials:

2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one

2-(3-(dihydrogen)phosphate-5-methoxyphenyl)-6,7-methylenedioxy-quinolin-4-one

3-(6,7-methylenedioxy-4-oxo-1,4-dihydroquinolin-2-yl)-5-methoxyphenyl dihydrogen phosphate

dibenzyl methyl phosphate