Methyl 3-(benzyloxy)-5-methoxybenzoate

Base Information

• Chemical Name: Methyl 3-(benzyloxy)-5-methoxybenzoate
• CAS No.: 50637-26-8
• Molecular Formula: C16H16O4
• Molecular Weight: 272.301
• DSSTox Substance ID: DTXSID40505943
• Nikkaji Number: J795.920F
• Wikidata: Q82361410
• Mol file: 50637-26-8.mol

Synonyms:Methyl 3-(benzyloxy)-5-methoxybenzoate;50637-26-8;SCHEMBL340311;DTXSID40505943;DAVQRPLIYCFEJK-UHFFFAOYSA-N;methyl 3-benzyloxy-5-methoxybenzoate;BB 0261779

Chemical Property of Methyl 3-(benzyloxy)-5-methoxybenzoate

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 272.10485899
• Heavy Atom Count: 20
• Complexity: 299

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)C(=O)OC)OCC2=CC=CC=C2

Technology Process of Methyl 3-(benzyloxy)-5-methoxybenzoate

There total 18 articles about Methyl 3-(benzyloxy)-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-hydroxy-5-methoxy-benzoic acid methyl ester (19520-74-2) + benzyl bromide (100-39-0) → methyl 3-(benzyloxy)-5-methoxybenzoate (50637-26-8)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Reflux;

DOI:10.1021/jo400737f

Reference yield: 96.0%

methyl 3-(benzyloxy)-5-hydroxybenzoate (54915-31-0) + methyl iodide (74-88-4) → methyl 3-(benzyloxy)-5-methoxybenzoate (50637-26-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.12.063

Reference yield: 96.0%

methyl 3-(benzyloxy)-5-hydroxybenzoate (54915-31-0) + dimethyl sulfate (77-78-1) → methyl 3-(benzyloxy)-5-methoxybenzoate (50637-26-8)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1016/S0960-894X(99)00305-4

upstream raw materials:

methanol

3-hydroxy-5-methoxy-benzoic acid methyl ester

benzyl chloride

diazomethane

Downstream raw materials:

3-(benzyloxy)-5-methoxybenzoic acid

(3-(benzyloxy)-5-methoxyphenyl)methanol

3-benzyloxy-5-methoxyaniline

(3-benzyloxy-5-methoxy-phenyl)-carbamic acid tert-butyl ester