(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

Base Information

Chemical Name:(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)
CAS No.:923274-44-6
Molecular Formula:C₃₇H₄₃N₅O₆S
Molecular Weight:685.844
Hs Code.:

(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

Synonyms:(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

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Chemical Property of (1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

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Technology Process of (1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

There total 8 articles about (1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 154350-29-5
cyclopropanesulphonamide

: 923274-43-5
(1R,2S)-1-{[(1R,2R,4R)-2-(hex-5-enyl-methyl-carbamoyl)-4-(2-phenyl-quinazolin-4-yloxy)-cyclo-pentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid

: 923274-44-6
(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

Guidance literature:: (1R,2S)-1-{[(1R,2R,4R)-2-(hex-5-enyl-methyl-carbamoyl)-4-(2-phenyl-quinazolin-4-yloxy)-cyclo-pentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

cyclopropanesulphonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 923274-44-6
(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

2.1: water / 0.68 h / 100 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 2.5 h / 0 - 20 °C

5.1: lithium hydroxide; water / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

5.2: pH 1

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 0.5 h / 100 °C / Microwave irradiation

With dmap; lithium hydroxide; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 862259-02-7
trans-(3R,4R)-3,4-bis(methoxycarbonyl)cyclopentanol

: 923274-44-6
(1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide)

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.1: pyridine; acetic anhydride / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

4.1: water / 0.68 h / 100 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 2.5 h / 0 - 20 °C

7.1: lithium hydroxide; water / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

7.2: pH 1

8.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

8.2: 0.5 h / 100 °C / Microwave irradiation

With pyridine; dmap; lithium hydroxide; sodium hydroxide; water; acetic anhydride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;