4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Base Information

• Chemical Name: 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester
• CAS No.: 851912-97-5
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 851912-97-5.mol

Synonyms:4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Chemical Property of 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

There total 3 articles about 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-Benzyloxycarbonyl-4-ethoxycarbonyl-3-oxopyrrolidine (51814-19-8) → 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester (851912-97-5)

Guidance literature:

With sodium cyanoborohydride; In methanol; pH 3-4;

DOI:10.1039/c39920001767

Reference yield:

ethyl 2-(benzyloxycarbonylamino)ethanoate (1145-81-9) → 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester (851912-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Na / toluene

2: 85 percent / NaCNBH₃ / methanol / pH 3-4

With sodium; sodium cyanoborohydride; In methanol; toluene;

DOI:10.1039/c39920001767

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) → 4-Hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester (851912-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Na / toluene

2: 85 percent / NaCNBH₃ / methanol / pH 3-4

With sodium; sodium cyanoborohydride; In methanol; toluene;

DOI:10.1039/c39920001767

upstream raw materials:

1-Benzyloxycarbonyl-4-ethoxycarbonyl-3-oxopyrrolidine

ethyl 2-(benzyloxycarbonylamino)ethanoate

ethyl acrylate

Downstream raw materials:

1-benzyl 3-ethyl 2,5-dihydro-1H-pyrrol-1,3-dicarboxylate

3-Chlorocarbonyl-2,5-dihydro-pyrrole-1-carboxylic acid benzyl ester

2,5-Dihydro-pyrrole-1,3-dicarboxylic acid 1-benzyl ester

5-Methoxy-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid benzyl ester