1145-81-9Relevant articles and documents
Electrochemical Dimethyl Sulfide-Mediated Esterification of Amino Acids
Li, Yongli,Wang, Huamin,Zhang, Heng,Lei, Aiwen
supporting information, p. 3023 - 3028 (2021/08/30)
Dimethyl sulfide-mediated electrochemical synthetic strategy for esterification of amino acids has been reported. A series of amino acids could react smoothly with alcohols, affording the desired esterification products with good efficiency. Importantly, the tolerance of peptides and gram-scale synthesis shed light on the utility of this protocol. Mechanistically, the dimethyl sulfide as a mediator plays an essential role in the transformation of amino acids.
Enantioselective synthesis of anti-β-hydroxy-α-amido esters by asymmetric transfer hydrogenation in emulsions
Seashore-Ludlow, Brinton,Villo, Piret,Somfai, Peter
supporting information; experimental part, p. 7219 - 7223 (2012/07/13)
Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of α-amido-β-ketoesters. These procedures yield the corresponding anti-β-hydroxy-α-amido esters in good yields and with good diastereo- and enantioselectivities. First, the scope of the reduction of α-amido-β-ketoesters by using triethylammonium formate azeotrope is examined. Then, an emulsion technology with sodium formate is explored, which allows for broader substrate scope, faster reaction times, and lower catalyst loading. Furthermore, these reactions are operationally simple and can be set up in air.
Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters
Smith, Alexander M.R.,Billen, Denis,Hii, King Kuok
supporting information; experimental part, p. 3925 - 3927 (2010/01/06)
Highly enantioselective α-hydroxylation of cyclic and acyclic 1,3-ketoesters can be achieved with up to 98% ee using a dicationic palladium(ii) catalyst and dimethyldioxirane as oxidant.
